Objective : To assess the oxidative
status and apoptosis in infants
and
children with febrile seizure.
Methods:
This study includes all children
having a febrile seizure either
simple
or complex. They were 40 patients
and tweenty children as control.
Blood sample was taken from
the
patients to measure serum total
anti-oxidant
capacity, MDA, soluble
Fas-L.
Data was analyzed using
SPSS
16. Results: We found that
children with FS had significantly
higher oxidative stress levels (higher
MDA 33.41±10.36 nmol/ml and lower
TAC median=0.55 Mm/L) (p≤0.001)
& higher evidence of apoptosis at
diagnosis (Median sFas-L 150 ng/L)
(p=0.003) than control group.
Conclusion: the present work provides
evidence for the increase in oxidative stress (higher MDA, lower
TAC) and apoptosis (higher s Fas-L)
when compared with control. Infection
or fever per se may affect oxidative
stress and apoptosis; which in
their
turn may cause and complicate
FS.
An inverse relationship between
TAC
and MDA leading to oxidative
stress
in FS. A correlation between
oxidative
stress and apoptosis.