Introduction: Excessive anxiety
has a bad implication on anesthetic
practice in pediatric anesthesia,
that is why to decrease anxiety by
premedication is an important issue.
Intranasal administration of various
drugs is an easy route with rapid
onset of action allowing administration
of a variable drugs such as
Midazolam
and Dexmedetomidine
used
in pediatric preoperative sedation.
Methodology: 64 children who
were submitted for elective ophthalmic
surgeries received either 0.5 mg/
kg
midazolam or 1µg/kg
dexmedetomidine
intranasally. Basal heart and respiratory rate, blood pressure,
sedation score and oxygen saturation
were recorded initially and every
5
minutes till the transfer to the operating
room. Sedation score was also
assessed
at 30 minutes after drug
administration.
Postoperative monitoring
was continued and any postoperative
complications were recorded.
Results: Oxygen saturation, heart
rate, systolic blood pressure and respiratory
rate values showed insignificant
differences when both groups
were
compared together, but
showed
significance differences
when
compared with the basal value
in
each group separately after 30 minutes. Sedation score was faster
and child-parents separation score
was higher in dexemedetomidine
group when compared with midazolam
group, also both groups showed
significant
sedation score less than 3
when
compared with the basal value
at
15,20,25,30 minutes .
Conclusion: Midazolam and dexmedetomidine
were nearly equally
effective
as intranasal premedication
for
pediatric patients submitted for
ophthalmic
surgery with minimal side
effects
and we recommend the use
of
midazolam due to its safety and
effectiveness
and low price .