The present study was designed to investigate : The chemical composition of artichoke fruit and leaves, the phenolic compounds content, antioxidant activity of fruit and leaves extracts of artichoke, and evaluation the effect of artichoke fruit and leaves on plasma lipid profile . Finally evaluation artichoke fruit and leaves on histopathological changes of liver in rats fed on hyperlipidemic diet . The result obtained through this work can be summarized in the following points . 1- Chemical composition of artichoke (Cynara scolymus L.) fruit and leaves :      The moisture, crude protein, crude fiber, ash, crude fats and total carbohydrate, in fruit and leaves were (83.8 and 79.4 %) , (3.05 and 1.976 %) ,(6.60 and 26.2 %) , (1.078 and 1.394 %) , (0.13 and 0.18 %) and (89.136 and 70.295 %) respectively . Total phenolic compounds in fruit of artichoke extract has been 32.7 mg / g meanwhile total flavonoids has been 12.3 mg / g , comparing with  19.5mg / g  and 5.7 mg / g  for total phenolic compounds and total flavonoids in leaves extracts respectively . 2- Phenolic compounds of artichoke (Cynara scolymus L.) fruit and leaves : Phenolic compounds in methanolic extracts of fruits and leaves of artichoke were analyzed by High Performance Liquid Chromatography (HPLC) , artichoke fruit were found to contain 11 phenolic compounds while artichoke leaves show only 12 phenolic compounds . Analysis of artichoke fruit showed that : benzoic acid , Ellagic acid , Gallic acid , P-hydroxy benzoic acid , caffeine , vanillic acid , o-coumaric acid , catechol , P- coumaric acid , salicylic acid , cinamic acid  are the major phenolic compounds . Meanwhile benzoic acid , ellagic acid , gallic acid , P-hydroxy benzoic acid , caffeine , ferulic acid , vanillic acid , caffeic acid , cyringic acid , cinamic acid  are the major phenolic ones in Artichoke – leaves .