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176269

CHEMICAL STUDIES ON SOME MEDICAL HERBS AGAINST GAMMA RADIATION INDUCED BIOCHEMICAL DISTURBANCE IN THE LIVER AND CARDIAC FUNCTIONS OF RATS

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Last updated: 26 Dec 2024

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Abstract

The objective of this study was to evaluate the ability of ginseng, green tea or/and cinnamon to improve the disturbances occur in liver, heart, lipid and thyroid profiles as well as antioxidant and lipid peroxidation status in rats as a result of exposure to γ-irradiation. The obtained results revealed a significant (p < 0.05) increase in serum alanine transferase (ALT), aspartate transferase (AST), lactate dehydrogenase (LDH) and creatine kinase (CK) activities as well as elevations in the levels of total cholesterol, triglycerides, high density cholesterol (HDL-Ch) and low density cholesterol (LDL-Ch) in irradiated rats than those in control ones. On the other hand, the concentrations of serum total protein, albumin and free triiodothyronine (FT3) were remarkable decreased in rats as a result of exposure to γ-irradiation. Moreover, as a result of exposure to γ-radiation, the mean value of GSH content and Gpx activity were remarkable decreased in both the liver tissues and in the cardiac tissues of the rats. On the contrary, the exposure to γ-radiation caused a significant (P<0.001) increment in thiobarbituric acid reactive substance (TBARS) level in both liver and heart tissues of rats. When γ-irradiated rats groups were treated with ginseng, green tea or cinnamon, considerable amelioration effects in all previous studied parameters were pronounced dependent on time of treatment (15 & 30 days). The maximum correction was occurred in all studied parameters in irradiated-rats treated with mixture of ginseng, green tea and cinnamon dependent on the time of treatment (15 and 30 days). So, this study can practically help to encourage the clinical use of this mixture as a treatment for exposure to γ-radiation. These mechanisms were discussed according to available recent researches.

DOI

10.21608/mjab.2017.176269

Keywords

Gamma Irradiation, taurine, Ginseng, green tea, Cinnamon, rat

Authors

First Name

M.A.

Last Name

Hammam

MiddleName

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Affiliation

Biochemistry Department. Faculty of Agriculture. Monofia University.

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Orcid

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First Name

M.I.A.

Last Name

Heibashy

MiddleName

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Affiliation

Nuclear Research Centre, Atomic Energy Authority.

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Orcid

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First Name

F.M.

Last Name

El-Shouny

MiddleName

-

Affiliation

Biochemistry Department. Faculty of Agriculture. Monofia University

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Orcid

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First Name

F.A.

Last Name

Shahin

MiddleName

-

Affiliation

Nuclear Research Centre, Atomic Energy Authority

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Volume

2

Article Issue

3

Related Issue

25543

Issue Date

2017-08-01

Receive Date

2021-06-08

Publish Date

2017-08-01

Page Start

29

Page End

41

Print ISSN

2357-0768

Online ISSN

2735-3532

Article File

MJAB_Volume 2_Issue 3_Pages 29-41.pdf

PDF . 626.9kB

Link

https://mjab.journals.ekb.eg/article_176269.html

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https://mjab.journals.ekb.eg/service?article_code=176269

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2

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original papers

Type Code

1,460

Publication Type

Journal

Publication Title

Menoufia Journal of Agricultural Biotechnology

Publication Link

https://mjab.journals.ekb.eg/

MainTitle

CHEMICAL STUDIES ON SOME MEDICAL HERBS AGAINST GAMMA RADIATION INDUCED BIOCHEMICAL DISTURBANCE IN THE LIVER AND CARDIAC FUNCTIONS OF RATS

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Article

Created At

23 Jan 2023