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161195

TOXICOLOGICAL AND BIOCHEMICAL EFFECTS OF AFLATOXINS ON EXPERIMENTAL RATS

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Last updated: 04 Jan 2025

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Abstract

Aflatoxins (AFs) are a group of highly toxic mycotoxins mainly produced by Aspergillus flavus and Aspergillus parasiticus, which are considered natural contaminants of food and feed toxic to the liver, carcinogens and mutagenic. Therefore, reducing their toxicity in the body of the organism is a great importance. In this study, the aqueous extract of leaves was evaluated (green Tea and sage) to reduce the toxicity caused by aflatoxins. Two concentrations of aflatoxins (0.5 and 1 mg / kg of b.w) were taken per week for 42 days, which led to a deterioration of liver and kidney function and the level of lipid and glucose in the plasma of the treated rats. In the laboratory experiment, the aqueous extract of the plants used greatly improved these traits after they were taken daily in concentrations (200-400 mg / kg of b.w) for a period of 42 days. Thus, it can be concluded that green tea and sage showed protective effect against aflatoxin toxicity.

DOI

10.21608/mjab.2021.161195

Keywords

Aflatoxins, Camellia sinensis, Salvia officinalis, Liver functions, kidney functions, Lipid profile, Antioxidant parameters

Authors

First Name

Sh. N.

Last Name

Draz

MiddleName

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Affiliation

Prof. of Biochemistry, Fac. of Agric., Menoufia Univ.

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Orcid

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First Name

A. M.

Last Name

Farid

MiddleName

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Affiliation

Prof. of Biochemistry, Fac. of Agric., Menoufia Univ.

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Orcid

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First Name

K. E.

Last Name

Hussein

MiddleName

-

Affiliation

Lecturer of Biochemistry, Fac. of Agric., Menoufia Univ.

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Volume

6

Article Issue

2

Related Issue

23625

Issue Date

2021-03-01

Receive Date

2021-04-05

Publish Date

2021-03-01

Page Start

23

Page End

24

Print ISSN

2357-0768

Online ISSN

2735-3532

Article File

MJAB_Volume 6_Issue 2_Pages 23-24.pdf

PDF . 354.9kB

Link

https://mjab.journals.ekb.eg/article_161195.html

Detail API

https://mjab.journals.ekb.eg/service?article_code=161195

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original papers

Type Code

1,460

Publication Type

Journal

Publication Title

Menoufia Journal of Agricultural Biotechnology

Publication Link

https://mjab.journals.ekb.eg/

MainTitle

TOXICOLOGICAL AND BIOCHEMICAL EFFECTS OF AFLATOXINS ON EXPERIMENTAL RATS

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Article

Created At

23 Jan 2023