Many studies have focused on the aging related hypertrophy and prostate injuries. The
use of natural product to prevent the prostate tissues degradation are of particular concern.
The study's aim was to determine the biological significance of whey supplementation in
optimizing aging-related changes in the structure and function of prostate of aged rats. Male
Wistar albino rats aged 8 and 30-months were categorized into two main groups with or
without whey supplementation (n=8). After two months of oral whey supplementation (2 ml,
twice doses/day), the rats were euthanized, blood was collected and serum was separated for
assessments of serum hormonal levels of testosterone and tri-and tetra-iodothyronin. The
prostate was dissected and processed for histological, immunohistochemical and transmission
electron microscopy.
The studies showed that whey supplementation alleviated the shrieked and atrophy of
prostate acini as well as hyperplasia of their lining epithelium. Whey supplementation also
decreased expression of the caspase 3 and prostate specific antigen (PSA)
immunohistochemistry. This was influenced by increased the immune reaction of
proliferating cell nuclear antigen (PCNA).This were also associated with improved the serum
hormonal levels of testosterone and triodo-and tetra-iodothyronine.
Finally the author finally concluded that whey supplementation improved properties
of aged properties and reduced hyperplasia, inflammatory lesions and collagenous
infiltration. Increased testosterone and thyroid hormonal levels were also found..