The efficiency of treatment was eliminated based on residual concentration of ammonia-nitrogen (NH4-N) and chemical oxygen demand (COD). Removal percentage of ammonia in case of using H2O2 increased in a concentration of 30%. the removal of organic pollutants recorded high efficiency of removal in 14.28 and 10.71% for east El-Burullus and Damru drains, respectively. KMnO4 gave better results which, the maximum ammonia removal was 66.59 % for 0.2 g/L of KMnO4 in Hokx site, whereas COD removal was 34.48 % at 0.1of KMnO4 in Hokx site. Acidic conditions (pH 3) demonstrated conducive to the removal of all factors for both oxidants with the exclusion of COD removal in Burullus east that displayed a high removal at pH 5. The reduction of NH4-N at pH 3 for both KMnO4 and H2O2, with 76.74%, 93.76%, 92.03 % for Burullus east, Damro and Hokx sites, respectively. whereas the higher percentage removal in COD was 23.07% and 8.97% for both Damro and Hokx sites at PH 3, while in Burullus east was 22.22% at pH 5. Furthermore, Fe2+/H2O2 (Fenton's reagent) was run in the batch process with various doss. Under the optimal parameters, the removal efficiency of COD was achieved 58. 69 % and 12.60 % for both Burullus east and Damro, respectively at Fe2+ =0.4 g/L, pH= 3 and contact time of 120 min. The NH4-N and COD removal performance of KMnO4 was well compared with H2O2. Finally, remediation needn't extra pH adjustment which it is simple operation and low capital cost.