Basically Human Resources Management (HRM) is a series of integrated decisions that form the employment relationship. The human resource department plays a major role in hotel industry in helping plan the system and performance standard. Human resource management methods are a crucial part of the HRM process, thus it's crucial to look into how they are being adopted in the service sector. Since the productivity and efficacy of people in firms primarily drive the service sector. This study aims to illustrate the impact of human resources management practices on organizational performance in a sample of five star hotels in Greater Cairo. To achieve this aim, a self-administered questionnaire was used to investigate the hotel employees' in terms of HR practices and its impact on organizational performance. A total of 300 forms distributed to hotel employees; 253 completed forms were valid representing 84% response rate. The findings showed that HRMP (selective hiring, employee training and compensation and rewards) positively affect organizational performance. The study recommended that hotels must have an effective recruitment strategy in order to hire qualified and competent employees.