This paper shows the importance of Geographic Information System (GIS) technology and Remote Sensing (RS) techniques' in their potentials to support decision making in the areas of planning, which managements, institutions and working organizations, especially future regional and habitable development field strategies seek; GIS and RS technologies with their special potentials to analyze, observe, register and unravel, besides many other features which the nature of those fields of study requires and which depends on a lot of spatial and descriptive information. GIS practices vary in the field of comprehensive and sustainable development. It is used in the management of the natural resources and environmental protection; as well as in the analysis of recurring functions and recurring activities during the management of cities; the controlling of habitant areas, and management of crisis and disasters; which is totally dependent on the adequacy and efficiency of information technology, which has become one of the most important industries that costs billions of dollars and accommodates thousands of employers all over the world; it is even taught in schools and universities worldwide Many organizations and institutions that rely on Geographic information System technology lay stress on its great role and view it from a new perspective different from the traditional Personal GIS one. The new perspective Enterprise GIS uses specialdatabases, which cure and analyze groups of different cases and studies in many fields. The most wide spread prominent Enterprise systems is the National Enterprise GIS which is executed by many governments around the world. Qatar's experience is the first andmost important worldwide overall experiment in National Enterprise GIS. It has become a unique model which many countries seek imitate such as Panama, Kuwait and many Arabic Gulf countries. This paper will study Qatar's experience and take it as a role model guide to see how far it can be applied in the development of Egypt. Keywords: Geographic Information System, GIS, Enterprise GIS, Comprehensive Development