The safe and economical design of bridge piles requires prediction of the maximum expected depths of scour of the stream bed around them. Scour at bridge piles may be defined as a local lowering in the bed elevation around the piles. A study of the local scour at bridge piles groups was experimentally and mathematically investigated. The case of six piles having the same diameter aligned with the flow direction in two rows altering the separation distance between the centerline of the three piles was established. The aim of this study is the investigation of the preferable separation distance between three piles to reduce scour around them to its minimum value. Artificial Neural Network (ANN) prediction models are more efficient in predictions models once they are trained from examples or patterns. These types of ANN models need large amount of data which should be at hand before thinking to develop such models. In this paper, the capability of ANN model to predict the maximum scour depth around bridge piles is investigated.