In this paper, a novel video transmission scheme for transmission of three dimensional set partitioning in hierarchical trees (3D-SPIHT) video coding streams over the CDMA channels is proposed. The main idea behind this scheme is that the output of the 3D-SPIHT video coding will be send related to its significant information. The modified 3D-SPIHT coder will generate three groups of bitstream. The significant bits, the sign bits, and the refinement bits are transmitted in three different groups. The optimal unequal error protection (UEP) of these groups is proposed. The RS code is used to test the effectiveness of the proposed scheme. In addition to UEP, the power optimization over the Code–division multiple access channels (CDMA) is done which increases the performance of our system. The simulation results indicate that the proposed scheme provides significantly better PSNR performance in comparison with the well-known robust coding schemes.