The effect of using industrial waste materials on the mechanical performance of hot mix asphalt was investigated. Two different types of industrial waste materials namely, white cement dust (WCD) and iron slag (IS) were tested. White cement dust was incorporated in the mixture as mineral filler while iron slag was incorporated as fine aggregate. Four waste materials contents were considered, namely; 0%, 10%, 20% and 30% by weight of mineral filler and fine aggregate for the cement dust and iron slag mixtures respectively. The mechanical performance of the studied mixtures was evaluated based on Marshall Properties, indirect tensile strength, and unconfined compressive strength. Laboratory testing has revealed an enhancement in the mechanical performance of asphalt concrete mixtures when cement dust was used. Marshall stability, the unit weight, the indirect tensile strength and the unconfined compressive strength increased with the increase of cement dust content. The flow, voids of total mix (% VTM) and voids of mineral aggregate (% VMA) values decreased as the cement dust content increased. The optimum asphalt content did not change significantly with the change in cement dust content. The mechanical testing has also indicated that, the iron slag has improved the mixture stability, unit weight and the unconfined compressive strength of the mixture. Using iron slag content more than 10% caused a significant reduction on the optimum asphalt content and the indirect tensile strength of the mixture.