With its two main aquifers that feed five villages and serve about 60000 capita, Al-Gofra Oasis, middle Libya, has seldom been subjected thoroughly for water quality evaluation. This paper aims at addressing the current situation of the groundwater at the oasis, studies the sources of pollution to the aquifers and introduces a methodology based on multivariate statistics for better monitoring and regular evaluation of the water quality at that oasis. Multiple Regression Analysis was used to correlate the field water quality data with the laboratory measured chemical parameters. Groundwater is the main/only source of water in that region. The aquifer in Sokna and Wadan is confined and its rocks consist of sand, clay and sandstone. The quality of water in this aquifer is fairly good and the Total Dissolved Solids (TDS) range between 1200 to 1500 ppm. The aquifer in Hun is deep confined aquifer and the quality of water is poor, where the TDS ranges between 4000 and 5000 ppm.