Energy crisis considered one of the most important challenges in the coming years due to future climate change and its negative effects as high values of air temperature and increasing energy demand for cooling purposes. In Egypt, the energy demand for cooling has been increased due to the increase in air temperature all over the republic. So, it became a very important issue to find a passive climatic solution. Phase Changing Materials (PCMs) considered as the best solution to decrease energy demand for cooling. Most international companies are currently competing in supporting the production of panels and rolls which depend on the integration with PCMs. This study depends on Design Builder software to evaluate the effect of Bio PCM Q23 and Bio PCM Q25 on energy consumption reduction. It was found that Bio PCM Q23 reduces the energy demand for cooling with an acceptable effectiveness percentage between 15.06% and 35.93% when combined with the building envelope, while the effectiveness of Bio PCM Q25 is between 18.93% to 97.93% when combined with the same building envelope.