Background: Hepatitis C virus continues to be a major public health problem all over the world especially in Egypt. Chronic hepatitis C impairs health related quality of life (HRQOL) even in the absence of severe morbidity; this suggests that, there are other factors can affect HRQOL of elderly patients with HCV. Identifying these factors can lead to improve their health related quality of life. So this study aimed to determine factors influencing HRQOL of geriatric patients with HCV. Three tools were used for data collection: Socio-demographic and clinical data structured interview schedule, Knowledge related to HCV structured interview schedule, and HRQOL of HCV patients structured interview schedule. It can be concluded that, chronic hepatitis C virus affected negatively most of the dimensions of patients' generic HRQOL. The majority of the study subjects have only partial knowledge about the disease and its mode of transmission.