Glioblastomas and metastasis are the most common brain tumors. Since each pathology has completely different means of clinical assessment as well as significantly varied therapeutic intervention, early diagnosis is crucial.
Both tumors have indistinguishable T1, T2, and FLAIR signals therefore process of identifying GBMs from brain metastases can be problematic, especially when a single brain lesion, suspected for a high-grade neoplasm, is discovered in a patient without a known original tumor. They are both surrounded by extensive peritumoral edema, where it is essentially vasogenic in metastatic tumors. However in GBM infiltrating neoplastic cells is reported. Therefore the key to distinguish between the two tumors lies in detecting the changes within the peritumoral edema. Differentiation between them is attempted through DWI. Several studies have shown that peritumoral ADC is useful for distinguishing between GBM and metastatic tumors.
AIMOFTHEWORK:
The aim of this work was to determine the diagnostic value of peritumoral minimum apparent diffusion coefficient for differentiation between glioblastoma multiform and solitary brain metastasis.