INTRODUCTION:
Annually, about millions ofhospital admissionse.g., US receive urinary catheterization. Catheter is a tube system inserted/placed to the body for draining urine for therapeutic or diagnostic purposes, but might cause UTI or urethral scarring. CRBD: burning sensation, stabbing pain, urge to urinate, discomfort on suprapubic region after catheterization. The rate of CRBD ranges 47%-90%.Contributing factors; male sex, open surgeries, previous catheterization, age ˂50yrs.
Pathogenesis: Activation of muscarinic receptors of cholinergic nerves, catheter triggering afferent nerves of the bladder resulting the release of Ach and involuntary contraction ofdetrusor muscles. Treatments; antimuscarinics, anaesthetics, antiepileptics, are frequently prescribed. IV dexmedetomidine: selective alpha2 adrenergic agonist with sedative, analgesics, antianxiety action without respiratory depression. It prevents CRBD by inhibiting M3 receptors. IV lidocaine has analgesic, anti-inflammatory and antihyperalgesic properties. Through analgesic and anti-inflammatory activities, itenhances postoperative recovery by opioid sparing and reducing immune alteration. It is assumed IV lidocaine has antimuscarinic properties.
AIM OF THE WORK:
The primary aim of the present work was to compare between intravenous lidocaine and dexmedetomidine infusion for prevention of postoperative catheter-related bladder discomfort (CRBD).
The secondary aim was to study the effects of these drugs (intravenous dexmedetomidine and lidocaine) on; Intraoperative and postoperative hemodynamics, Postoperative analgesia and Sedation status of the patients.