Introduction:
Doxorubicin is a highly effective and widely used chemotherapeutic agent in treating wide variety of tumors. Unfortunately, cardiotoxicity is its most serious side effect, which is directly linked to the oxidative stress caused by DOX. Resveratrol is a powerful antioxidant, but its low bioavailability limits its use. Multilamellar liposomes are lipid nanocarriers. They are recently used as a carrier to enhance the bioavailability of many drugs by increasing their plasma half-life.
Aim of the work:
The current study was designed to histologically assess the myocardial alterations following induction of cardiotoxicity in adult male albino rats by doxorubicin and to evaluate the possible protective efficacy of RSV-loaded multilamellar liposomes on DOX-induced cardiotoxicity.
Materials and methods:
The present study was conducted over 5 successive weeks on 30 adult male albino rats which were categorized into 2 equal groups. Group I which was subdivided randomly into 3 equal subgroups: subgroup IA received physiological saline twice/week by intraperitoneal (i.p) injection, subgroup IB received daily oral suspension of unloaded multilamellar liposomes and subgroup IC received daily oral suspension of RSV-loaded multilamellar liposomes. Group II which was also equally subdivided into 3 subgroups (IIA, IIB and IIC), all of which received i.p injection of add the dose DOX twice/week I.P. for 5 successive weeks. In addition, subgroups IIB and IIC received daily oral suspension of unloaded multilamellar liposomes, and RSV-loaded multilamellar liposomes respectively. At the end of the experiment, cardiac apices specimens of all rats were obtained, processed and examined by light and electron microscopes.