INTRODUCTION:
Diabetes mellitus is a serious, long-term disease with a global prevalence 10.5% in 2021. Type 2 diabetes and insulin resistance remained one of the most adjustable risk factors for the development of dementia and AD, with a twofold increased risk of accelerated cognitive decline, dementia and cognitive impairment. Brain Derived Neurotrophic Factor (BDNF) is a key molecule posing survival and growth promoting actions on a variety of neurons, including hippocampal and cortical neurons, involved in plastic changes related to learning and memory. It plays a major role in synaptic plasticity, neuronal differentiation and survival, neuroprotection, and neuronal resilience and restoration against broad range of cellular insults. In addition, it has a key role in regulating axonal and dendritic growth and guidance, long-term potentiation (LTP) and participation in neurotransmitter release
AIM OF THE STUDY:
The present study aimed of comparing metformin and insulin use on cognitive status manifested by Mild cognitive impairment (MCI) using mini mental status examination (MMSE) and its relation to serum BDNF.