Diabetic nephropathy (DN) occurs in 40% of patients with diabetes mellitus (DM) diagnosed clinically by presence of albuminuria andor reduced eGFR in the absence of signs and symptoms of other primary cause of renal damage.
Since serum creatinine concentration not depends only on GFR but many additional factors such as muscle mass, sex, age, diet and pharmacological treatment. So, we in need for novel biomarker of decreased GFR without increased albuminuria before the kidneys are irreversibly damaged.
Serum osteoinductive factor (OIF) belong to small leucine rich repeat proteoglycans (SLRP)family and it is a secretory protein.
Recent studies suggest that OIF may play a direct role in DN through the development of renal fibrosis and atherosclerosis of renal arteries.
Aim of the work:
Our study aimed to asses serum OIF as a marker of early DN in patient with type 2 DM and its correlation with albuminuria and eGFR in different stages of the disease.