Drug induced nephrotoxicity is the presence of any kidney injury caused by medications.This nephrotoxicity may be manifested as acute kidney injury (AKI), chronic kidney injury (`CKI), or any other clinical renal manifestations. Cisplatin is one of the most common drugs documented to cause nephrotoxicity. It causes nephrotoxicity by many mechanisms. First, it is mainly excreted by the kidney through tubular secretion. Within the tubular cells, cisplatin conjugate with water forming hydrates which cause DNA damage, oxidative stress, and apoptosis. Also, Cisplatin induces renal cell apoptosis via three ways; death receptors exogenous pathway, endoplasmic reticulum stress pathway (ERS), and mitochondria mediated endogenous pathway. Platelet –rich plasma (PRP) is an autologous human plasma. It is a mixture of highly concentrated platelets, growth factors, and bioactive molecules. It may play a major protective role in cases of cIt activates the tissue regeneration through cell proliferation and differentiation cisplatin –induced nephrotoxicity because of its high content of growth factors.