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EVALUATION OF MATERNAL SERUM PENTRAXIN 3 AS A NOVEL DIAGNOSTIC BIOMARKER IN GESTATIONAL DIABETES MELLITUS

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Last updated: 26 Dec 2024

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Abstract

Gestational diabetes mellitus (GDM) is the type of glucose intolerance that develops in the second and third trimester of pregnancy, resulting in hyperglycemia of variable severity. It is the most common metabolic disorder of pregnancy.
The oral glucose tolerance test (OGTT) is considered the cornerstone of the diagnosis of gestational diabetes mellitus (GDM). Earlier detection of GDM may lead to improved management, possibly preventing pregnancy complications. Thus, the identification of sensitive and specific biomarkers, which may offer potential for risk prediction and intervention strategies, became a major focus in GDM research.
Pentraxins are a superfamily of evolutionarily conserved molecules with multi-functional roles in innate immunity and inflammation. They are essential constituents of the humoral arm of innate immunity and represent a superfamily of highly conserved acute phase proteins. Pentraxin 3 (PTX3) is the prototype of the long pentraxin subfamily.
In recent years, chronic subclinical inflammation is considered to have a potential role in the pathogenesis of hyperglycemia and pentraxin 3 (PTX3) as an inflammatory mediator, is correlated with the process of insulin resistance and its level is also increased in diabetes mellitus and diabetic nephropathy.
The OGTT is beloved by very few, and validation of alternative, less cumbersome strategies for diagnosis and classification of GDM are needed.

DOI

10.21608/alexpo.2022.124724.1377

Keywords

gestational diabetes mellitus (GDM), oral glucose tolerance test (OGTT), Pentraxin 3 (PTX3)

Authors

First Name

Mohamed

Last Name

Khamis

MiddleName

Yousri

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University

Email

yousrikh@yahoo.com

City

-

Orcid

-

First Name

Manal

Last Name

Swelem

MiddleName

Shafik

Affiliation

Department of obstetrics and gynaecology, Faculty of medicine

Email

manalshafikswelem@gmail.com

City

-

Orcid

-

First Name

Marwa

Last Name

Khedr

MiddleName

Ibrahim Abdelhalim

Affiliation

Department of Medical Biochemistry, Faculty of Medicine, Alexandria University

Email

marwa.khedr@alexmed.edu.eg

City

-

Orcid

-

First Name

Bassant

Last Name

Ibrahim

MiddleName

Saeed Basyouni

Affiliation

Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University

Email

bsb18289@gmail.com

City

-

Orcid

-

Volume

4

Article Issue

1

Related Issue

29866

Issue Date

2022-03-01

Receive Date

2022-03-01

Publish Date

2022-03-01

Page Start

46

Page End

47

Online ISSN

2682-2636

Link

https://alexpos.journals.ekb.eg/article_224772.html

Detail API

https://alexpos.journals.ekb.eg/service?article_code=224772

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1

Type

Preliminary preprint short reports of original research

Type Code

1,426

Publication Type

Journal

Publication Title

ALEXMED ePosters

Publication Link

https://alexpos.journals.ekb.eg/

MainTitle

EVALUATION OF MATERNAL SERUM PENTRAXIN 3 AS A NOVEL DIAGNOSTIC BIOMARKER IN GESTATIONAL DIABETES MELLITUS

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Article

Created At

23 Jan 2023