Functional Mitral regurge in advanced Heart failure dilated cardiomyopathy patients is a strong predictor to mortality this arouses to study the impact of Cardiac resynchronization therapy on functional MR in DCM.
AIM OF WORK
The aim of our study was to assess the effect of cardiac resynchronization therapy on the severity of mitral valve regurgitation among patients with DCM.
PATIENTS AND METHODS:
This is a prospective observational study of Twenty-five patients with advanced heart failure DCM with sinus rhythm LBBB wide QRS≥ 130 ms with at least moderate MR, subjected to CRT implantation at Alexandria main university Hospital and followed up by Echocardiography after CRT by 1 week and 10 weeks and comparing between improved MR (GroupI) and stable MR grouppatients (Group II).
RESULTS:
Evidence of early response to CRT was observered in 9 patients (36%), MR improvement among responders to CRT was observed in 7 patients (77.8%) and was higher among early echocardiographic responders (48%) than among early clinical responders (40%), and is significantly association with percent of reduction in QRS width in surface ECG. (P value: 0.026). FMR improvement observed in 15 patients (60%) ‘Group I' (p value