Obesity is a highly heritable multifactorial disease that places an enormous burden on human health. Its increasing prevalence and concomitant-reduced life expectancy has intensified the search for new analytical methods that can reduce the knowledge gap between genetic susceptibility and functional consequences of the disease pathology.(1)
Genetic polymorphism is a difference in DNA sequence among individuals, groups, or populations. Sources include single nucleotide polymorphisms (SNPs), sequence repeats, insertions, deletions, and recombinations. Genetic polymorphisms may result by chance, or may be induced by external agents as viruses or radiation.(2)
IL-6 released from skeletal muscle may have beneficial effects on glucose control, but IL-6 released from adipose tissue can lead to liver insulin resistance. Adipocyte-derived IL-6 promotes adipose tissue macrophage accumulation in the absence of major changes in insulin tolerance, whereas myeloid cell-derived and muscle-derived IL-6 suppresses M1-like macrophage polarization and adipose tissue macrophge accumulation and improves insulin tolerance.(3)
AIM OF THE WORK:
The aim of the work was to study interleukin-6 gene polymorphism and other clinical, laboratory, and radiological parameters to differentiate between simple and complicated obesity.