Infertility is considered to be a disease process worthy of investigations and treatment. ART is one of options available to achieve pregnancy in infertile couples. ICSI is a technique used during in vitro fertilization. (LH) surge was a major impediment led to the cancellation of many IVF cycles. (GnRH-a) was introduced as a method of pituitary down-regulation used to prevent a premature LH surge. There is more emphasis on safer protocols reducing incidence of OHSS; therefore, antagonist regimens would be the treatment of choice in hyper-responders. The administration of estradiol in the luteal phase is one of these methods used for achievement of follicular synchronization in antagonist cycles as it may induce FSH receptor formation in more resistant follicles and may result in more coordinated gonadotropin response. We decided to verify whether luteal E2 could produce coordination of follicular growth during COH and improve ICSI results.
AIM OF THE WORK
The aim of this work was to study the effect of estradiol pretreatment on follicular synchronization and intracytoplasmic sperm injection (ICSI) outcome in antagonist cycles.