Endometrium is one of the main factors in implantation and pregnancy. Pregnancy rate is increased with growing endometrial thickness. (EMT) Most patients with the standard medical therapies reach the desired endometrial thickness and small numbers of patients fail to reach the minimum EMT. The empirical preference for EMT for implantation is >7 mm.
Intrauterine infusion of platelet-rich plasma (PRP) is a new approach that has been suggested for the treatment of thin endometrium as it is widely used in various fields. PRP is blood plasma prepared from fresh whole blood that has been enriched with platelets. Itcontains several growth factors that stimulate proliferation and growth.
Aim of the work:
Aim of this work was to evaluate the effect of intra-uterine infusion of platelet-rich plasma (PRP) in frozen embryo transfer cycles: effect on the endometrial thickness and clinical pregnancy rates in women with refractory thin endometrium.
Subject and Methods
Women who had a history of failed IVF cycles and refractory thin endometrium were enrolled in this study. The main inclusion criteria were EMT of≤ 7 mm after more than 2 cycles of previous medical therapy for increasing the EMT.