Breast cancer (BC) is the most frequent type of tumors among females.Until a palpable or visible lump develops within the breast, there are no symptoms or indicators correlated with BC.The main issue with serum markers in BC is finding one that is both specific and sensitive for women with tiny or early lesions. Techniques based on lncRNAs are expected to have great sensitivity making them useful in therapeutic settings. As a result, MALAT-1 could be investigated as a novel biomarker in the diagnosis, prognosis, metastasis, and the prediction of treatment responses in solid tumours. Also many trace elements such as selenium has been shown to play a substantial role in a variety of biological processes.As a consequence, it is reasonable to expect that these trace elements will have an effect on carcinogenic development.
Aim of the work:
Evaluate the possible significance of circulating MALAT1 as potential biomarker for BC in Egyptian female patients.
Assess the possible relation of serum selenium concentration and MALAT1 expression in BC patients.