Acute kidney injury (AKI) is clinically defined as acute decrease in glomerular filtration rate (GFR) reflected by rising serum creatinine (SCr) and/or drop in urine output over a given period of time. The incidence rates of AKI are affected by both the definition of AKI used and the studied population.
Neutrophil gelatinase-associated lipocalin (NGAL) also referred to as lipocalin 2, It belongs to the Lipocalin glycoproteins family.
Platelets and lymphocytes (PLR) plays critical roles in the inflammatory process. It is novel inflammatory factor that has received research attention recently, as it may act as an indicator of inflammation. (NGAL) has been recently highlighted as a biomarker for acute kidney diseases.
AIM OF THE WORK
The aim of the work was to compare accuracy of platelet-to-lymphocyte ratio to serum gelatinase associated lipocalin as a predictor of the morbidity and mortality in critically ill patients with acute kidney injury.
SUBJECTS AND METHODS
This study was carried on sixty adult patients of both sex who were admitted to the Critical Care Medicine Department in Alexandria Main University Hospital with diagnosis of AKI.
Serum NGAL was measured for all patients on admission and PLR was calculated for all patients.
Patients were followed up for 28 days and the following were recorded; length of ICU stay, need for vasopressors, need for mechanical ventilation, need for renal replacement therapy and 28-day mortality.
Patients were classified into two groups according to mortality; Group I (survival) & Group II (non-survival).