Psoriatic arthritis (PsA) is an inflammatory arthritis, usually develops in patients with psoriasis.Patients who have PsA may have skin and nail disease with joint inflammation and may also have other manifestations like enthesitis, uveitis, dactylitis, axial inflammatory arthritis, metabolic syndrome and constitutional manifestations related to long term inflammation, such as fatigue.Obesity and PsA are linked by a common pathophysiological mechanism, which is chronic low-grade inflammation. Adipocytes show an imbalance resulting in an excessive secretion of inflammatory mediators known as adipokines. These adipokines include leptin, TNF-α , plasminogen activator inhibitor-1 (PAI-1) and interleukin-6 (IL-6).In particular, an increased prevalence of obesity has been reported in PsA as compared with the general population, suggesting that obesity may be a predisposing factor for PsA. On the other hand, PsA may be a predisposing factor for obesity because of functional and/ or psychological limitations.
Aim of the work:
Aim of the work to investigate the relationship between Psoriatic arthritis and obesity.