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190044

COMPARISON OF 18F-FDG-PET/CT VERSUS WB DW-MRI IN STAGING AND EVALUATION OF RESPONSE FOR LYMPHOMA PATIENTS

Article

Last updated: 26 Dec 2024

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Abstract

The aim of the study is to assess the diagnostic value of Whole Body DWI in the staging and assessment of treatment response in lymphoma as a viable alternative in comparison to FDG PET/CT. a prospective study enrolled 20 lymphoma patients including aggressive and indolent subtypes D for staging or treatment response assessment. The lesions detected by MRI-DWI were evaluated with PET/CT as the reference standard. The impact of DWI and PET/CT on disease staging was analyzed according to Ann Arbor. The mean age at diagnosis was 58.44 (SD ± 5.16) years. 90% (18/20) had NHL. 6/20 patients were recruited for treatment response. The other 14 patients had 100% agreement in staging; 9were stage IV, 1 stage III, 1 stage II, and 3 were stage I disease. The agreement was moderate (κ = 0.57)for Total nodal sites and very good (κ = 0.84) for extranodal sites. Discordance in extranodal sites in 2 cases included: splenic infiltration at DWI on one and focal Bone Marrow infiltration at FDG PET/CT on the other. Individual sites showed a good agreement κ> 0.69 except for hilar region with a poor agreement (κ = 0.35) but this did not impact staging.DWI is a good alternative to FDG PET/CT and can be used in varied lymphomas and as an alternative for radiation-free imaging due to its good level of agreement to the standard reference. It showed a good evaluation especially of extranodal sites and also nodal sites except for hilar LNs where FDG PET/CT remains superior

DOI

10.21608/alexpo.2021.86452.1233

Keywords

DWI - Diffusion-weighted imaging, Lymphoma, FDG PET/CT, Ann Arbor staging

Authors

First Name

mwanajaa

Last Name

mwachui

MiddleName

abdalla

Affiliation

Alexandria university

Email

mmwachui@gmail.com

City

alexandria

Orcid

-

First Name

Ahmed

Last Name

Gowily

MiddleName

-

Affiliation

Alexandria Clinical Oncology Department, Faculty of Medicine, Alexandria University, Alexandria Egypt.

Email

ahmed_elgowily@yahoo.com

City

Alexandria

Orcid

-

Volume

3

Article Issue

4

Related Issue

28719

Issue Date

2021-12-01

Receive Date

2021-07-28

Publish Date

2021-12-01

Page Start

26

Page End

27

Online ISSN

2682-2636

Link

https://alexpos.journals.ekb.eg/article_190044.html

Detail API

https://alexpos.journals.ekb.eg/service?article_code=190044

Order

195

Type

Preliminary preprint short reports of original research

Type Code

1,426

Publication Type

Journal

Publication Title

ALEXMED ePosters

Publication Link

https://alexpos.journals.ekb.eg/

MainTitle

COMPARISON OF 18F-FDG-PET/CT VERSUS WB DW-MRI IN STAGING AND EVALUATION OF RESPONSE FOR LYMPHOMA PATIENTS

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Type

Article

Created At

23 Jan 2023