Acute myeloid leukemia (AML) characterized by clonal myeloid precursor proliferation with decreased differentiation into more mature cells which lead to an accumulation of leukemic blasts in the bone marrow, peripheral blood, and occasionally in other tissues and the development of normal red blood cells , platelets and mature granulocytes is decreasing.
Febrile neutropenia is a medical emergency that requires urgent evaluation, the timely administration of empiric broad-spectrum antimicrobials, and careful monitoring to optimize patient outcomes and diminish the risk of complications.
A new definition of sepsis, termed (Sepsis-3) as life-threatening organ dysfunction caused by a dysregulated host response to infection.
Recently, non-invasive assessment of platelet turnover has been performed by measuring the immature platelet fraction (IPF). The percentage of reticulated platelets indicates the degree of platelets damage and the generation of platelets in bone marrow.
AIM OF THE WORK
To evaluate the immature platelet fraction in acute myeloid leukemia patients receiving chemotherapy as a predictor of onset of sepsis by comparing it to C reactive protein and serum ferritin.