INTRODUCTION
Chronic rhinosinusitis with nasal polyposis (CRSwNP) comprises heterogeneous clinical pictures and can be categorized into two types: eosinophilic type and non-eosinophilic one. The allergy role in the pathogenesis of CRSwNP is still debatable. T-cell-mediated immune reaction may play a significant role in eosinophilic CRSwNP. The count of eosinophils has been positively correlated with the count of mast cells and the remaining inflammatory cells as a whole. Human papillomavirus (HPV) was strongly accused in the development of inverted papilloma, but it has not been searched adequately as the culprit for the development of CRSwNP.



AIM OF THE WORK
The present research aimed to detect HPV in patients with CRSwNP, find any relation between HPV and tissue eosinophilia.




PATIENTS AND METHODS
The study had been conducted on a total number of 90 patients. All patients are asked to withhold steroids and antihistamines four weeks before taking samples and excluded for mucociliary dysfunction or immunodeficiency. A computed tomography (CT) scan on nasal and paranasal sinuses had been dictated before taking sample for all patients. A blood sample for detection of blood eosinophilia was withdrawn from all patients with CRSwNP. PCR was done for HPV detection in both diseased and control groups. Histopathological examination for polypoidal specimens was done for tissue eosinophilic count and percentage among other inflammatory cells.