Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. Cirrhosis is the most important risk factor for the development of HCC. The most widely adopted staging system is the Barcelona Clinic Liver Cancer (BCLC) algorithm, which links prognosis of HCC with the best treatment option based on strong clinical evidence. One of the loco-regional interventional therapies that plays a major role in the current therapeutic management of HCC, is microwave ablation (MWA). The applied electromagnetic field causes water molecules to rotate billions of times per second, which leads to heat generation and cellular death via coagulation necrosis. The prognosis of HCC remains unsatisfactory, thus novel molecular markers are needed to predict tumor biology and identify patients with higher risk of metastasis or recurrence. Human U three protein 14a (hUTP14a), a member of the U three proteins (UTPs) family, is one of the nucleolar proteins, that play an important role in unregulated replication of defective DNA, genomic instability and progression to cancer, through promoting degradation the tumor suppressor protein p53.