Apple scab caused by Venturia inaequalis (Cooke) G. Wint., is the most serious fungal disease affecting apple trees in many apple production areas of the world and Egypt, that resulting in the defoliation of trees and making the fruits unmarketable. Depending on the risk of disease, 8 to 10 or even more fungicidal applications usually need for efficient control. If the disease is not controlled at the suitable time of application, the disease can affect 70 % or more of the yield. Field studies were conducted during 2017 and 2018 growing seasons in two districts of two Governorates of Egypt, i.e. Qalyoubia at El-Qanater El-Khayria Horticultural Research Station, Agricultural Research Center, and Beheira at a private farm at Kafr El Dawar. The efficiency of different tested fungicides and the time of their application (four variable times) on controlling the disease and fruit yield production were estimated. Time of application have markedly affected the efficiency of the fungicides that used. Disease suppression and fruit yield (kg/tree) were greater when the tested fungicides were applied at the third application program (at fruit set in the first week of April when the first symptoms of scab infection were observed), followed by the second application program (at full bloom in the first week of March), while fungicide applications at the first application program (at bud burst in the first week of February) and the fourth application program (at fruit growth in the first week of May) recorded the highest disease severity% and the lowest yield productivity (kg/tree) in the two governorates through the two growing seasons. Bellis, Amistar top and Score had more effect on apple scab infections and yield productivity (kg/tree), followed by Occidor, Topsin M and Namrod but the lowest efficiency% and the lowest productivity of yield (kg/tree) were recorded with Dithane M, Index, Copper oxychloride and Microvit through 2017 and 2018 growing seasons in the two governorates. Sulphur and copper, however, gave acceptable control for apple scab when used at an appropriate time.