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117172

TOXIC EFFECTS OF TWO NEONICOTINOID INSECTICIDES, THIAMETHOXAM AND ACETAMIPRID, ON THE SWISS ALBINO MICE

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Last updated: 26 Dec 2024

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Abstract

The objectives of this study were to study the toxic effects of two neonicotinoids insecticides, acetamiprid and thiamethoxam, on the Swiss albino mice through: 1)   Determine acute toxicity (for 24 hours) of both pesticides and monitor behavioral alternations of animals exposed to different doses for 14 days. 2)   Study the effects of sub-lethal dose (1/20,1/50 and 1/100 of LD50) of acetamiprid and thiamethoxam on physiologicalaspects (behavioral alternations and body weight), haematological parameters (RBCs,HGB,HCT, MCV, HCT,LYM,MID, WBCs, MCH and platelets) 3)   Biochemical analysis (AST, ALT, albumin, total protein, bilirubin and cholesterol) in liver, (creatinine; urea, and uric acid) in kidney . Antioxidants and oxidative stress parameters were also determined in serum of treated animals. 4)   Examine the possible histopathological alternations in liver, kidney, lung and tests tissues of animals exposed to sub lethal doses of acetamiprid and thiamethoxam. 5)   Study selenium effect as a protective source of antioxidant to enhance toxic effects caused by repeated sub lethal doses of acetamiprid and thiamethoxam.

DOI

10.21608/mjapam.2019.117172

Keywords

Acetamiprid -thiamethoxam, Antioxidants -oxidative stress- histology

Authors

First Name

G. E.

Last Name

Abouelghar

MiddleName

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Affiliation

Prof. of Pesticides, Fac. of Agric., Menoufia Univ.

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Orcid

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First Name

Zeinab A.

Last Name

El-Bermawy

MiddleName

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Affiliation

Prof. of Pesticides, Fac. of Agric., Menoufia Univ.

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Volume

4

Article Issue

2

Related Issue

17671

Issue Date

2019-04-01

Receive Date

2020-10-05

Publish Date

2019-04-01

Page Start

67

Page End

68

Print ISSN

2357-0776

Online ISSN

2735-3494

Article File

MJAPAM_Volume 4_Issue 2_Pages 67-68.pdf

PDF . 257.1kB

Link

https://mjpam.journals.ekb.eg/article_117172.html

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https://mjpam.journals.ekb.eg/service?article_code=117172

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5

Type

Original Article

Type Code

1,417

Publication Type

Journal

Publication Title

Menoufia Journal of Plant Protection

Publication Link

https://mjpam.journals.ekb.eg/

MainTitle

TOXIC EFFECTS OF TWO NEONICOTINOID INSECTICIDES, THIAMETHOXAM AND ACETAMIPRID, ON THE SWISS ALBINO MICE

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Article

Created At

23 Jan 2023