Giza 6 common bean plants (salt-sensitive) were grown in saline-treated soil before planting in the 2019 and 2020 summer seasons. It was treated with 3 levels of salinity (zero) control at a concentration (0.65 E.C), the first salinity level at a concentration (3 E.C.) and the second salinity level (6 E.C.), to study the effect of salinity on the growth and development of common bean plant, physiological and biochemical changes and yield. The bean seedlings were treated 30, 45 and 60 days after sowing with some nano-stimulators such as (Nanosilicon 2mM), polyamine 1Mm), seaweed extract (0.5 ml/L) and bio-fertilizer (7 g/kg seed) with the use of distilled water as control. During that experiment, it was found that salinity negatively affected all growth parameters and reduced (root and stem length, number of leaves and branches, fresh and dry weight, leaf area, net assimilation rate (NAR), relative growth rate (RGR) and salt tolerance index (STI) . The treatment with salt also led to an increase in the membrane permeability rate and a decrease in the relative water content, as well as an increase in the activity of the enzyme polyphenol oxidase and peroxidase, amino acids, total phenols and proline, while it led to a decrease in the content of total sugars and photosynthesis pigments. The accumulation of sodium increased and also the ratio of Na⁺/K⁺ and the ratio of Na⁺/Ca⁺², while the concentration of K⁺, Ca⁺², P and N decreased and the final yield of the seed crop. Applied of nano stimulators, especially nanosilicon and bio-fertilizer, as well as seaweeds extract, the harmful effect of salinity decreased and led to an improvement in all growth parameters,  physiological and biochemical estimates, which led to a decrease in the permeability of plasma membranes and an increase in the activity of oxidative enzymes, proline, total amino acids, elements, and the accumulation of sodium and both the ratio Na⁺/K⁺ and the ratio of Na⁺/Ca⁺² decreased and increase seed yield for both plant and feddan.