A pots experiment was conducted in cage-house at Wheat Research Department and the laboratory of Soil Improvement and Conservation Department, Sakha Agricultural Research Station, Agricultural Research Center, Egypt in 2015/2016 and 2016/2017 seasons. The stepwise regression analysis method used to determine the most effective characteristics related to wheat grain yield under three salinity levels. The data collected on five characteristics groups i.e., seedling, phenological, spike, physiological, yield and its contributes. The results showed that, the salinity levels less than 3.5 dSm-1 did not negatively affect wheat seedling growth, while, increasing salinity levels more than 3.5 dSm-1 significantly decreased all studied seedling characteristics. The salinity level of 3.5 dSm-1 led to earliness percentage of 4.2, 4.9, 3.8 and 2.2% in booting, heading, anthesis and maturity developmental stages, respectively. Meanwhile, increasing salinity levels up to 10.5 dSm-1 caused decrease for emergence speed by 21.7% and delay booting, heading and anthesis developmental stages by 3.9, 10.8 and 8.5%, respectively. Salinity stress decreased flag leaf area and increased chlorophyll pigments concentration, where the increase percent was higher for chlorophyll a compared with chlorophyll b and the total chlorophyll. Salinity stress decreased all studied spike characteristics with strong effect on number of kernels spike-1 and spike kernels weight. Salinity stress decreased yield and its contributes where its effect was strong on plant height, root dry weight, biological and grain yield. The stepwise regression showed that biological yield, spike kernels weight, emergence index, number of spikes pot-1 and hundred kernels weight under salinity stress are the important selection criteria of high grain yield.