The present study was carried out at the Experimental Farm of Sakha Agricultural Research Station, Kafrelsheikh, Egypt during season of 2019 and 2020 seasons, to study the effect of water deficit at the reproductive and ripening stages on performance of some rice genotypes. Fourteen genotypes were used in this investigation; two of them are used as checks, NERICA 7 as tolerant to drought and Giza 177 as sensitive to drought. The results of this research showed that all rice varieties and their traits were affected significantly by water stress at reproductive stage and ripening stage. The water stress at reproductive stage reduced significantly number of panicles plant-1. While the drought stress at ripening stage decline significantly the number of filled grains panicle-1 and 1000-grain weight and grain yield tha-1. The reductions in grain yield due to drought at the ripening stage were 53.14 and 54.00 % compared with well-watered in 2019 and 2020 seasons, while, the reduction in grain yield attributed to water stress at the reproductive stage is 38.55 and 43.50 % in both seasons. All rice varieties were affected significantly by water stress at ripening stage followed by the water stress at reproductive stage. The grain yield reduction differed among the rice varieties according to their level of tolerance, the reduction in grain yield due to water stress at both ripening and reproductive stages for the sensitive variety Giza 177 was about 81.3 and 54.8%, respectively compared with well-watered. Meanwhile, the lowest reduction percentage in grain yield under the same conditions was recorded for NERICA 7 and NERICA 8. The cultivar with the highest values of anatomical traits is considered as drought tolerant as NERICA 7 and Giza 178. Grain yield was positively correlated with root length, root dry weight, number of panicles plant-1 and 1000-grain weight under water stress at reproductive stage. However, grain yield was positive and highly correlated with root thickness, number of filled grains panicle-1 and 1000-grain weight under water stress at ripening stage.