Two field experiments were carried out at the Experimental Farm of Sakha Agricultural Research Station, Kafrelsheikh, Egypt during 2017 and 2018 summer seasons to study the impact of rice cultivars and chemical control on weedy rice in drill-seeded rice. Three rice cultivars (Giza 178, Giza 177 and Sakha 101) were used. Fifteen weedy rice chemical control treatments, viz, thiobencarb (3.57 kg ai ha-1) at 4 DAS alone or followed by fenoxaprop-ethyl, bispyribac-sodium and propanil (recommended doses) at 35, 18 and 20 DAS, respectively, pendimethalin (2.023 kg ai ha-1) at 4 DAS alone or followed by fenoxaprop-ethyl, bispyribac-sodium and propanil as recommended, oxadiazon (0.595 kg ai ha-1) at 4 DAS alone or followed by fenoxaprop-ethyl, bispyribac-sodium and propanil by recommended rates, in addition to fenoxaprop-ethyl, bispyribac-sodium and propanil (as post-emergence herbicides) by recommended doses as compared with weedy check and weedy rice free plots were applied. A split-plot design arranged in randomized complete block with three replications was used in both seasons. Main plots were devoted to common rice cultivars while, the sub-plots included weedy rice control treatments in both seasons. The results showed Giza 178 appeared the best competitiveness ability against red rice and significantly reduced dry weight and grain yield of red rice, consequently produced the highest dry weight, yield and yield attributes of cultivated rice as well as reduced yield losses in 2017 and 2018 seasons. Under heavy infestation of weedy rice, oxadiazon at 4 DAS followed by fenoxaprop-ethyl at 35 DAS recorded the lowest dry weight, grain yield ha-1 of red rice as well as the highest weedy rice control efficiency percent, moreover the best cultivated rice growth, yield and its attributes as well as minimized yield losses to 27.9% as average in both seasons. It could be concluded that, under heavy infestation of weedy rice, cultivating Giza 178 rice cultivar and the application of oxadiazon at rate of 0.595 kg ai ha-1 at 4 DAS followed by fenoxaprop-ethyl under rate of 0.0625 kg ai ha-1 applied at 35 DAS can achieve the best weedy rice control, highest cultivated rice growth, yield and yield attributes under drill-seeding conditions.