Fifteen Barki ram were used to study the effect of MOL or MOSC supplementation in the ration on IR, MAD, TAC, IgG, IgM, WBCs, serum transaminases and renal function. The rams were divided into 3 groups. Rams in G1 were fed a basal diet supplemented with MOL (0.5% of CFM/day), rams in G2 were fed a basal diet supplemented with MOSC (10% of CFM/day) while G3 were fed a basal diet without supplementation. The results indicated that supplementation with MOSC increased antibodies after immunization, TAC and decreased MAD in blood samples of rams fed a ration containing MOSC or MOL compared to those rams fed moringa-free rations in contrast to the activity of MAD.  The highest IgG recorded in blood samples of rams fed MOl followed by that measured in rams fed MOSC, the lowest was for rams fed a Moringa-free ration. However, the highest IgM recorded in rams fed MOSC followed by that in rams fed a Moringa-free ration and the lowest for rams fed ration with MOL. MOSC or MOL supplementation slightly increased WBC and neutrophil cells, supplementation of rams with MOSC significantly reduced creatinine and GPT compared to those supplemented with MOL or the control group. It can be concluded that feeding supplementation ration of Barki rams with MOSC can increase antibody production, WBCs, neutrophils, TAC and decreased MAD, having a positive effect on kidney function and liver enzymes, and enhances the immunity status of rams.