In Egypt, buffalo considered one of an important economic and social reality productive profits, for the national income in our country. So, calf health and its management are considered one of the most actual problems during colostrum and subsequent growth periods. calves suffered from failure of passive transfer of maternal immunoglobulin's may be at risk of disease and be more susceptible to mortality due to low consuming Ig from colostrum or are unable to efficiently absorb IgG causing a major economic loss for livestock producers. This study was conducted at the Animal Production Research Station of Mehallet Mousa, belonging to Animal Production Research Institute (APRI), Agricultural Research Center, longitude, Kafr Al -Sheikh governorate, Egypt. It was arranged with the Animal Production Department, Faculty of Agriculture, Al -Minufiya University, Shibin El-Kom- Minufiya, Egypt. Chemical analysis and hormonal assay were carried out in APRI labs. A total number of 50 female buffalo raised in El-Nattaf  El-Kadeem farm followed Mehallet Mousa station were available to this experiment, chosen representing different parities (1 to 5) aging 3 to 7 years old and weighting about 350 to 675 kg. It lasted for 5 months from November 2017 to March 2018. We found that dams' parity, live body weight, body condition score and calf sex affected immunoglobulin's concentration (IgA, IgM and IgG), Glucose, Creatinine, T3&T4, acute phase proteins (TAC, Fb, and SAA), calves live body weight, Interleukin ( IL-1 and IL-6),  average daily weight gain of buffalo calves, hemoglobin concentration, hematocrit, RBCs and WBCs in calves blood plasma.