Aiming at investigating the predictive power of the Egyptian General Secondary Certificate (GSC) official English exam scores and their relation to EFL achievement at university, the researchers analyzed the scores for a large sample of 234 pharmacist freshmen. Moreover, gender differences were also examined. Three hypotheses were posed for the quest. Data were collected from the GSC official exam as well as the freshmen's college exam. In terms of statistics, simple linear regression was used to analyze data and find the predictive relation between the variables. Results unearthed that GSC official English exam scores had a significant power as a predictor of EFL freshmen's college achievement in English. It was also found that there were gender differences for females' sake in this concern. Consequently, the researchers provided some recommendations for developing the GSC exam and improving male students' performance.