In this study, synthetic and biological soil conditioners were used to screen their abilities to improvise the barren soil characters. These soil conditioners based on treatment of barren soil samples with urea and / or compost as synthetic soil conditioner or by inoculating the soil samples with Spirulina meneghiniana Zanrd. ex Gomon and / or Anabaena oryzae Fritsch as a biological soil conditioner. The data revealed that, the biological conditioner in a mixture (22.5 kg ha^-1 Anabaena and 22.5kg ha^-1 Spirulina supplied with 7.5 kg ha^-1 urea and 7.5 kg ha^-1 compost) was the most effective one. Also, the soil samples inoculated with this mixture exhibited positive activity of improving soil characters. Moreover, highly significant positive responses of the development features were appeared on lettuce plants transplanted in such soil samples.