SARS-Coronavirus-2 is a new virus infecting people and causing COVID-19 disease which is considered a worldwide pandemic. Out of its great danger, Arab media and the Ministry of Health try to handle everything about it and identify its clinical signs and symptoms. In this research, the researcher tries to discuss its dangers and the reasons behind its spread in addition to covering its social and human dimensions. She employs semiotics in portraying Arab media depiction of this serious disease. As Arab caricaturists have exploited drawings in shedding light on the sufferings of the whole world upon the spread of this disease, a set of caricatures presented by Arab caricaturists in Arab newspapers and social media will be analyzed, using Roland Barthes' Elements of Semiology which have been developed in 2000 by Robert Seiler. The chosen theory gives the analysis the necessary structure and provides the needed tools for the analysis. The researcher attempts to indicate that we live in a world of signs, and through their denotations we can explore reality.