In this study, many design parameters in cyclone such as cone height (30, 50 and 70 cm), vortex finder length (0, 10, 20, 30 and 40 cm) and dipleg length (25, 40 and 55 cm) were investigated under operating parameters via inlet air velocity (14, 16, 18 and 20 m/s) to find out the pressure drop (ΔP) of the cyclone empirically and predictively. The ΔP between inlet and outlet of the cyclone was measured experimentally by differential inclined manometer, while some mathematical models were used to predict ΔP of cyclone based on Shepherd and Lapple (1939), Barth (1956), Casal and Martinez-Benet (1983), Dirgo (1988) and Coker (1993). Some statistical indicators were used to compare and validate the measured with predicted results. As a result of this experiment, the maximum empirical ∆P were 161.3, 181.7 and 250.8 Pa recorded at inlet air velocity of 20 m/s, cone heights of 30, 50 and 70 cm under vortex finder lengths of 40, 40 and 0 cm and dipleg lengths of 55, 25 and 25 cm, respectively. Meanwhile, the minimum ∆P were 60.2, 63,6 and 80.6 Pa recorded at inlet air velocity of 14 m/s, cone heights of 30, 50 and 70 cm under vortex finder lengths of 10, 30 and 40 cm and dipleg lengths of 25, 55 and 55 cm, respectively. Furthermore, the best models to predict the pressure drop were Shepherd & Lapple, Coker and Dirgo, respectively. The Shepherd & Lapple model was more validation with cone heights of 50, 30 and 70 cm, respectively. Meanwhile, the predicted model Coker was more validation with cone heights of 30, 50 and 70 cm, respectively. While, Dirgo model was more validation to experimental data at vortex finder length of 20 cm then 30 and 10 cm, respectively.