Travel agencies mainly depend on staff with high qualifications, skills, and experiences that can contribute to their success and enhance competitiveness. Job descriptions identify the characteristics and responsibilities required for each job. Moreover, job descriptions are necessary for implementing various human resources management activities, including selection and recruitment, performance evaluations, training, and compensation. This study aims to investigate the awareness and use of job descriptions in Egyptian travel agencies. It also examines the contents of a job description, and shows its importance as a strategic human resource management practice. The sample chosen in this study includes 165 managers, employees, and human recourses managers in Egyptian travel agencies. This study reveals that there is a relationship between job descriptions and human resource functions. The results also determine that the selection and recruitment process is the most prominent human resource function with regard to applying job descriptions.