This study explores the factors affecting job performance in three-star hotels in Greater Cairo, Egypt. Based on the literature discussed, six factors were considered as the vital components influencing employees' performance that should be examined. The research question depends on which factors have a concurrent and partial effect on employee performance. The finding revealed that being male has a significant influence on four of the organizational factors that affect employee performance. These factors are commitment; empowerment; promotion justices; salaries and compensations. While, being female gender has a significant influence on three of organizational factors that affect employee performance. These factors are displayed as: promotion justices; commitment; salaries and compensations. In addition, the variable of work experience has no significant influence on all the organizational factors that affect employee performance. The value of the determination coefficient test was 63 %, which means that linear regression explains the variance in the data, while the remaining of 37% is described by other factors. Moreover, the F test showed that training, empowerment, and salaries have partial effect on employee performance, while managerial standards, commitment and promotion variables have no effect on employee performance.