COVID-19 in Saudi Arabia has emerged across different regions of the country. To date, the Makkah region has seen the highest number of COVID-19 cases, containing 39.5%of all cases in Saudi Arabia. To understand the risk of COVID-19, the population and population density of the region were investigated. Examining the number of COVID-19 cases could provide useful insights for officials when considering the adoption of different interventions. To obtain this data, a local spatial analysis using Geographically Weighted Regression (GWR) was employed to predict the risk of COVID-19 for the Makkah Region. A strong positive association (R² =0.96) was found between COVID-19 and population and population density in Makkah region. The cities with the highest population and population density were found to be at a higher risk of COVID-19.