Background: Purpose of This retrospective study for assessment of hepatic tumor response to the anti-angiogenic drugs via perfusion CT.
Aim of the work: To elucidate the role of CT perfusion in characterization and differentiation of hepatic focal lesion and give a true assessment of the hemodynamic status of the liver parenchyma.
Patients and Methods: This study will be done on patients presenting with proven hepatic focal lesion after abdominal CT with IV contrast media injection, Perfusion parameters collected.
Results: Our study suggests that perfusion parameters obtained in liver effectively discriminate between ROIs that contain malignant or metastatic lesions from sites containing healthy liver tissues.
Moreover, the resulting characteristics are potentially useful for prognostication and staging, since it has been demonstrated that tumors exhibiting high vascularity tend to be more aggressive and respond poorly to chemotherapy and radiation therapy.
Conclusion: CT perfusion imaging of the liver provides functional information about the microcirculation of normal parenchyma and focal liver lesions and is a promising technique for assessing the efficacy of various anticancer treatments.