Background: Giant cell tumors (GCT) are benign tumors that may have aggressive behavior, it is usually found peri-articular, (Distal femur, proximal tibia, distal radius) with unclear pathogenesis. Aim of the Work: To detect best method of treatment of aggressive giant cell tumor whether intralesional curettage or resection and replacement with endoprothesis.
Patients and Methods: This review was a randomized controlled trial that studied the lines of surgical treatment of aggressive giant cell tumor. This review included studies that were published in English, studies that included surgical treatment only not conservative treatment and studies that published on PubMed or Medline. Results: As regard the tumor location, the number of sample cases was 315, including 169 cases distal Femur and 146 Case proximal tibia with no statistical significant difference between the included studies. Regarding the follow up time, the number of sample cases was 166 with highly statistical significant difference between the included studies. Conclusion: Throughout this systematic review, we concluded that Wide resection and extended curettage using adjuvants in treatment of patients with giant cell tumor were equally effective with no statistically significant differences in complications.